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Octacationic Cyclophanes: Binding of ATP and Other Anionic Guests in Water
Author(s) -
Menger Fredric M.,
Catlin Kelly K.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199521471
Subject(s) - chemistry , molecule , aqueous solution , aqueous medium , stereochemistry , host–guest chemistry , cyclophane , nitrogen , crystallography , calixarene , ring (chemistry) , supramolecular chemistry , organic chemistry
Macrocyclic host molecule 1 with eight quaternary nitrogen atoms within the ring can bind anionic guests (including ATP) in aqueous media. X‐ray structure analyses and NMR studies show that the guests do not enter the cavity; instead they associate with the host externally through a surprisingly efficient ion‐exchange mechanism.