Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt( II ) Complexes | Zendy

Nagata Takushi | Zendy; Yorozu Kiyotaka | Zendy; Yamada Tohru | Zendy; Mukaiyama Teruaki | Zendy

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Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt( II ) Complexes

Author(s) -

Nagata Takushi,

Yorozu Kiyotaka,

Yamada Tohru,

Mukaiyama Teruaki

Publication year - 1995

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199521451

Subject(s) - sodium borohydride , enantioselective synthesis , optically active , chemistry , catalysis , cobalt , sodium , enantiomeric excess , reducing agent , borohydride , medicinal chemistry , combinatorial chemistry , organic chemistry

Asymmetric reduction of prochiral ketones with sodium borohydride proceeds in the presence of catalytic amounts of optically active β‐oxoaldiminatocobalt( II ) complexes 1 to the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities (68–94% ee ).

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