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Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β‐Oxoaldiminato)cobalt( II ) Complexes
Author(s) -
Nagata Takushi,
Yorozu Kiyotaka,
Yamada Tohru,
Mukaiyama Teruaki
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199521451
Subject(s) - sodium borohydride , enantioselective synthesis , optically active , chemistry , catalysis , cobalt , sodium , enantiomeric excess , reducing agent , borohydride , medicinal chemistry , combinatorial chemistry , organic chemistry
Asymmetric reduction of prochiral ketones with sodium borohydride proceeds in the presence of catalytic amounts of optically active β‐oxoaldiminatocobalt( II ) complexes 1 to the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities (68–94% ee ).