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Endotoxin Antagonists: Possible Candidates for the Treatment of Gram‐Negative Sepsis
Author(s) -
Holst Otto
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199520001
Subject(s) - lipid a , sepsis , escherichia coli , disaccharide , gram , microbiology and biotechnology , gram negative bacteria , bacteria , chemistry , lipopolysaccharide , pharmacology , biology , biochemistry , immunology , genetics , gene
The acylation and phosphorylation pattern determines the effectiveness of disaccharide antagonists of lipid A (lipid A from Escherichia coli is shown on the right), the toxic principle of sepsis‐inducing endotoxins from Gram‐negative bacteria. These antgonists, which have not shown toxic activity for humans, have now been synthesized.