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Platination Pathways for Reactions of Cisplatin with GG Single‐Stranded and Double‐Stranded Decanucleotides
Author(s) -
Barnham Kevin J.,
Sadler Peter J.,
BernersPrice Susan J.,
Frenkiel Tom A.,
Frey Urban
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199518741
Subject(s) - cisplatin , chemistry , oligonucleotide , nuclear magnetic resonance spectroscopy , dna , combinatorial chemistry , stereochemistry , reaction intermediate , reaction mechanism , computational chemistry , biochemistry , catalysis , chemotherapy , medicine , surgery
1 H, 15 N correlated NMR spectroscopy has proven to be a suitable method to investigate the reaction of the anticancer drug cisplatin cis ‐[PtCl 2 (NH 3 ) 2 ] ( 1 ) with DNA. All the intermediates in reactions of 1 with complementary model oligonucleotides can be detected with this method; one of these intermediates is shown.