Platination Pathways for Reactions of Cisplatin with GG Single‐Stranded and Double‐Stranded Decanucleotides | Zendy

Barnham Kevin J. | Zendy; Sadler Peter J. | Zendy; BernersPrice Susan J. | Zendy; Frenkiel Tom A. | Zendy; Frey Urban | Zendy

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Platination Pathways for Reactions of Cisplatin with GG Single‐Stranded and Double‐Stranded Decanucleotides

Author(s) -

Barnham Kevin J.,

Sadler Peter J.,

BernersPrice Susan J.,

Frenkiel Tom A.,

Frey Urban

Publication year - 1995

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199518741

Subject(s) - cisplatin , chemistry , oligonucleotide , nuclear magnetic resonance spectroscopy , dna , combinatorial chemistry , stereochemistry , reaction intermediate , reaction mechanism , computational chemistry , biochemistry , catalysis , chemotherapy , medicine , surgery

1 H, 15 N correlated NMR spectroscopy has proven to be a suitable method to investigate the reaction of the anticancer drug cisplatin cis ‐[PtCl 2 (NH 3 ) 2 ] ( 1 ) with DNA. All the intermediates in reactions of 1 with complementary model oligonucleotides can be detected with this method; one of these intermediates is shown.

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