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Synthetic Receptors Based on Vinylogous Sulfonyl Peptides
Author(s) -
Gennari Cesare,
Nestler H. Peter,
Salom Barbara,
Still W. Clark
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199517651
Subject(s) - tripeptide , sulfonyl , sequence (biology) , molecule , chemistry , stereochemistry , receptor , combinatorial chemistry , peptide , biochemistry , organic chemistry , alkyl
The tripeptide sequence ( L ‐Pro)‐( D ‐Val)‐( D ‐Pro) is recognized by a tweezerlike molecular receptor constructed from vinylogous sulfonyl peptides (see diagram on the right). The screening of this tweezer molecule against a combinatorial tripeptide library reveals interesting sequence specifities for this new class of receptors. DR = dye molecule (Disperse Red 1), • = polystyrene support.