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Estramycins: A New Diyl Precursor Family Derived from Estradiol
Author(s) -
Wang Jing,
De Clercq Pierre J.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199517491
Subject(s) - enediyne , diradical , chemistry , stereochemistry , combinatorial chemistry , physics , nuclear physics , singlet state , excited state
The protected enediyne 1 is the first example of an estramycin, a new family of potential anticancer antibiotics, derived from estradiol. Important for therapeutic applications is the cyclization of the enediyne unit, which proceeds via a diradical intermediate. R 1 R 3 Ac; R 2 SiMe 3 .
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