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Catalytic Asymmetric Carbonyl–Ene Reactions
Author(s) -
Berrisford David J.,
Bolm Carsten
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199517171
Subject(s) - ene reaction , enantioselective synthesis , allylic rearrangement , catalysis , chemistry , lewis acids and bases , organic synthesis , medicinal chemistry , organic chemistry
Practical options for catalytic and enantioselective CC bond formation have been extended by recent developments reported by the Carreira and Mikami groups in reactions of aldehydes with alkenes containing an allylic H atom [Eq. (a)]. These studies link two fascinating and topical areas of organic synthesis—carbonyl–ene chemistry and the use chiral Lewis acids.