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A New Application of Capillary Zone Electrophoresis: Determination of Energy Barriers of Configurationally Labile Chiral Compounds
Author(s) -
Weseloh Gerald,
Wolf Christian,
König Wilfried A.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199516351
Subject(s) - racemization , capillary electrophoresis , enantiomer , chemistry , electrophoresis , capillary action , chromatography , combinatorial chemistry , materials science , organic chemistry , composite material
The direct determination of the rates of racemization of configurationally labile, chiral compounds like 1 is now possible with capillary zone electrophoresis. The method obviates the isolation of the enantiomers before the enantiomerization experiment, which is required in chiroptical methods, and the computer simulations necessary for dynamic procedures.