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Burial of Hydrocarbon Causes Cooperative Enhancement of Electrostatic Binding
Author(s) -
Sharman Gary J.,
Searle Mark S.,
Benhamu Bellinda,
Groves Patrick,
Williams Dudley H.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199514831
Subject(s) - hydrocarbon , electrostatics , chemistry , solvent , solvent effects , energy transfer , ligand (biochemistry) , binding energy , peptide , chemical physics , photochemistry , computational chemistry , stereochemistry , organic chemistry , receptor , physics , biochemistry , atomic physics
The introduction of alanine methyl groups in adjacent positions on a peptide ligand results in a cooperative enhancement of electrostatic binding from the burial of hydrocarbon. This observation may explain why larger changes in free energy occur when hydrocarbon substituents are buried in a molecular recognition site than can be accounted for by the solvent transfer model (classical hydrophobic effect).