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First Synthesis of 2 H ‐Azepine
Author(s) -
Hamprecht Dieter,
Polborn Kurt,
Steglich Wolfgang
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199514691
Subject(s) - azepine , bicyclic molecule , chemistry , organic chemistry , stereochemistry , combinatorial chemistry
Highly volatile and unstable in the pure form , the 2 H ‐azepine 1 has been synthesized for the first time. This compound is a “spin‐off” from work on the chemistry of azepine alkaloids, which occur in the mushroom Chalciporus piperatus . In addition, a bicyclic product of a surprising Diels–Alder reaction forms in the cyclization step.