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The Role of Dehydroalanine in Catalysis by Histidine Ammonia Lyase
Author(s) -
Langer Martin,
Pauling Andrea,
Rétey János
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199514641
Subject(s) - dehydroalanine , histidine , chemistry , deamination , lyase , imidazole , residue (chemistry) , nucleophile , ammonia , stereochemistry , catalysis , biochemistry , amino acid , enzyme
Not the α‐amino group but the 5‐position of the imidazole ring functions as a nucleophile towards the prosthetic dehydroalanine residue in the deamination of histidine catalyzed by histidine ammonia lyase (HAL) [Eq. (a)]. The results discussed here strongly support this proposal.