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Rapid Water Diffusion in a Cage‐Type Crystal Lattice: β‐Cyclodextrin Dodecahydrate
Author(s) -
Steiner Thomas,
da Silva Aida M. Moreira,
TeixeiraDias José J. C.,
Müller Jörn,
Saenger Wolfram
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199514521
Subject(s) - crystal structure , molecule , crystallography , cyclodextrin , chemistry , lattice (music) , diffusion , kinetics , cage , materials science , stereochemistry , physics , thermodynamics , organic chemistry , mathematics , combinatorics , quantum mechanics , acoustics
Despite the absence of water channels , H/D and H 2 16 O/H 2 18 O exchange experiments show that water molecules diffuse rapidly through the crystal lattice of β‐cyclodextrin · 12H 2 O (CD). Exchange takes place in minutes and follows first‐order kinetics. This is explained by the structural fluctuations of the β‐CD molecules, which became apparent in crystallographic studies and in computer simulations.