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Efficient Total Synthesis of the Pharmacophore of the Anticancer Antibiotic CC‐1065 by Zirconocene‐ and Palladium‐Initiated Cyclizations
Author(s) -
Tietze Lutz F.,
Buhr Wilm
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199513661
Subject(s) - pharmacophore , moiety , palladium , chemistry , stereochemistry , combinatorial chemistry , antibiotics , bromobenzene , total synthesis , organic chemistry , biochemistry , catalysis
Three steps suffice for constructing the pyrroloindolino framework of the pharmacophoric moiety 2 of the highly potent anticancer agent CC‐1065. The easily accessible bis(allylamino)bromobenzene 1 was transformed by successive cyclizations mediated by [Cp 2 Zr(Me)Cl] and by a Pd° complex.