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Synthesis of a Dynemicin A Analogue and Its Bergaman‐Type Cycloaromatization
Author(s) -
Takahashi Takashi,
Sakamoto Yasuharu,
Yamada Haruo,
Usui Shuji,
Fukazawa Yoshimasa
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199513451
Subject(s) - enediyne , stereochemistry , combinatorial chemistry , type (biology) , chemistry , biology , ecology
An efficient and simple approach is described here for the synthesis of enediyne 1 , a model compound for the antibacterial and anticancer agent dynamicin A. Compound 1 undergoes the cycloaromatization reaction characteristic of such enediyne systems and can conceivably be attached to various “drug delivery systems” through the two ester groups.