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Palladium‐Catalyzed Amination of Aryl Halides—Catalysts on New Routes to Known Targets
Author(s) -
Beller Matthias
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199513161
Subject(s) - catalysis , halide , amination , aryl , palladium , chemistry , amine gas treating , tin , combinatorial chemistry , base (topology) , organic chemistry , mathematics , mathematical analysis , alkyl
It's the base that matters! Sodium tert ‐butoxide can be used to facilitate Pd‐catalyzed CN couplings directly with the amine. This was shown by research by Hartwig et al. and Buchwald et al. Thus, the use of ecologically unsound tin amides in the hetero‐Heck reaction may be avoided in future. Further improvement of the catalysts to make them industrially more interesting, and the extension of the method to CO couplings is eagerly awaited.