Premium
The Structure of the D. gigas [NiFe] Hydrogenase and the Nature of the Hydrogenase Nickel Complex
Author(s) -
Halcrow Malcolm A.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199511931
Subject(s) - hydrogenase , nickel , bioinorganic chemistry , chemistry , crystallography , stereochemistry , enzyme , biochemistry , organic chemistry
Several surprises came to light in the recent single‐crystal X‐ray structural determination of a [NiFe] hydrogenase by Volbeda et al. For example, the Ni fraction of the enzyme clearly forms part of an unprecedented cysteine‐bridged heterometallic binuclear system. In retrospect, the feasibility of such a structural motif is evident from the known coordination chemistry of nickel thiolate complexes. But the mechanism of H 2 oxidation by this NiFe(?) complex remains tantalizingly opaque and continues to challenge bioinorganic chemists.