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Novel Genetically Engineered Tetracenomycins
Author(s) -
Decker Heinrich,
Haag Sabine,
Udvarnoki Györgyi,
Rohr Jürgen
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199511071
Subject(s) - streptomyces fradiae , genetically engineered , streptomyces , gene , genetically modified organism , biology , microbiology and biotechnology , genetics , computational biology , bacteria , actinomycetales
Genetically engineered hybrid strains , in which the genes of the urdamycin‐producer Streptomyce fradiae are combined with some of the biosynthetic genes of the elloramycin‐producer Streptomyces olivaceus or the genes of the tetracenomycin‐producer Streptomyces glaucescens , assemble novel hybrid antibiotics of the tetracenomycin type. The results prove that this combinatorial biosynthesis method may be a useful alternative for the production of new natural products which can then be screened.