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Synthesis of an RGD‐Sialyl‐Lewis X Glycoconjugate: A New Highly Active Ligand for P‐Selectin **
Author(s) -
Sprengard Ulrich,
Kretzschmar Gerhard,
Bartnik Eckart,
Hüls Christoph,
Kunz Horst
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199509901
Subject(s) - glycoconjugate , chemistry , selectin , sialyl lewis x , peptide , amine gas treating , stereochemistry , ligand (biochemistry) , conjugate , combinatorial chemistry , biochemistry , adhesion , receptor , organic chemistry , mathematical analysis , mathematics
Complex saccharide‐peptide conjugates are accessible through an efficient fragment condensation in which the partially protected RGD peptide is coupled with the sialyl Lewis X amine unit to form 1 . Compound 1 is the most potent antagonist for P‐select‐in yet reported.
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