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Solid‐Phase Syntheses of Unnatural Biopolymers Containing Repeating Urea Units
Author(s) -
Burgess Kevin,
Shin Hunwoo,
Linthicum D. Scott
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199509071
Subject(s) - peptidomimetic , amide , solid phase synthesis , urea , chemistry , combinatorial chemistry , amino acid , phase (matter) , organic chemistry , biochemistry , peptide
New “oligourea”‐based peptidomimetics are the subject of this communication. Two new derivatives of this type, including the Leu‐enkephalin analog 1 , have been prepared by addition of suitably protected isocyanates to amino acids supported on Rink's amide resin. The chemistry described is designed for solid‐phase approaches to combinatorial libraries by split syntheses.