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Combinatorial Biosynthesis–An Approach in the Near Future?
Author(s) -
Rohr Jürgen
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199508811
Subject(s) - polyketide , gene , computational biology , biology , biosynthesis , synthetic biology , genetics
A gene library has been conceived for the construction of multienzyme complexes from natural and altered building blocks. The first encouraging results have been achieved with polyketide synthases (PKSs): enzyme hybrids were formed by “mixing” genes coding for PKSs, which provide novel polyketides such as 1 . The ring frameworks, configurations, and/or functional groups of these novel compounds depend on the manipulated genes.