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A Simple, Chirogenic, Enantioselective Synthesis of Chlorins and Isobacteriochlorins
Author(s) -
Kusch Dirk,
Töllner Elke,
Lincke Anngret,
Montforts FranzPeter
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199507841
Subject(s) - enantioselective synthesis , geminal , chirality (physics) , chemistry , amide , stereochemistry , combinatorial chemistry , acetal , organic chemistry , catalysis , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Geminal dialkylated hydroporphyrins are important as intermediates of the vitamin B 12 biosynthesis or as cofactors of reducing enzymes in bacteria and plants. They can be synthesized enantioselectively by asymmetric reduction of acylporphyrins and amide acetal Claisen rearrangement with transfer of chirality, and can form complexes like 1 with metals.