Triple‐Helix Formation of Oligodeoxynucleotides Containing [(3′ S ,5′ R )‐2′‐Deoxy‐3′,5′‐ethano‐β‐ D ‐ribofuranosyl]nucleosides (“Bicyclo‐deoxynucleosides”) | Zendy

Bolli Martin | Zendy; Leumann Christian | Zendy

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Triple‐Helix Formation of Oligodeoxynucleotides Containing [(3′ S ,5′ R )‐2′‐Deoxy‐3′,5′‐ethano‐β‐ D ‐ribofuranosyl]nucleosides (“Bicyclo‐deoxynucleosides”)

Author(s) -

Bolli Martin,

Leumann Christian

Publication year - 1995

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199506941

Subject(s) - oligonucleotide , triple helix , nucleobase , stereochemistry , chemistry , dna , nucleic acid , helix (gastropod) , rna , biochemistry , biology , gene , ecology , snail

An enhanced preference for complexing to an RNA complement on the Hoogsteen side of the nucleobase is the consequence of the sugar modification in oligonucleotides of bicyclodeoxyguanosine 3 . Furthermore, oligonucleotides containing bicyclothymidine 1 and bicyclodeoxycytidine 2 provide evidence of specific differences in the preferred sugar conformation of the nucleosides in the third strand in DNA triple helices.

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