Premium
Triple‐Helix Formation of Oligodeoxynucleotides Containing [(3′ S ,5′ R )‐2′‐Deoxy‐3′,5′‐ethano‐β‐ D ‐ribofuranosyl]nucleosides (“Bicyclo‐deoxynucleosides”)
Author(s) -
Bolli Martin,
Leumann Christian
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199506941
Subject(s) - oligonucleotide , triple helix , nucleobase , stereochemistry , chemistry , dna , nucleic acid , helix (gastropod) , rna , biochemistry , biology , gene , ecology , snail
An enhanced preference for complexing to an RNA complement on the Hoogsteen side of the nucleobase is the consequence of the sugar modification in oligonucleotides of bicyclodeoxyguanosine 3 . Furthermore, oligonucleotides containing bicyclothymidine 1 and bicyclodeoxycytidine 2 provide evidence of specific differences in the preferred sugar conformation of the nucleosides in the third strand in DNA triple helices.