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A Non‐Peptidic Ion Channel with K + Selectivity
Author(s) -
Tanaka Yasutaka,
Kobuke Yoshiaki,
Sokabe Masahiro
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199506931
Subject(s) - ion , selectivity , conductance , chemistry , ion channel , resorcinol , analytical chemistry (journal) , inorganic chemistry , crystallography , physics , catalysis , condensed matter physics , biochemistry , receptor , organic chemistry , chromatography
The resorcinol–octadecanal cyclotetramer 1 forms an ion channel in planar lipid bilayers. A stable conductance level is observed with well‐defined transitions between open and closed states. The channel discriminates K + from Na + ions as well as cations from anions (for example, K + from Cl − ), as indicated by permeability ratios of 3 and 20, respectively. Rb + ions block the K + ion current.