Titanium‐Induced Zipper Reactions | Zendy

Fürstner Alois | Zendy; Ptock Arne | Zendy; Weintritt Holger | Zendy; Goddard Richard | Zendy; Krüger Carl | Zendy

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Titanium‐Induced Zipper Reactions

Author(s) -

Fürstner Alois,

Ptock Arne,

Weintritt Holger,

Goddard Richard,

Krüger Carl

Publication year - 1995

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199506781

Subject(s) - zipper , intramolecular force , ketone , regioselectivity , amide , chemistry , titanium , yield (engineering) , coupling reaction , combinatorial chemistry , stereochemistry , organic chemistry , materials science , catalysis , mathematics , algorithm , metallurgy

Remarkably high chemo‐ and regioselectivity was found in the intramolecular one‐pot McMurray‐type reaction between ketone and amide carbonyl groups. A simple preparative method is used by which the active low‐valent titanium species is formed selectively at the site of the reductive coupling. For example, compound 2 is formed from 1 in 86% yield by a zipper‐like series of carbonyl couplings.

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