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The Three‐Dimensional Structure of Hammerhead Ribozymes
Author(s) -
Sczakiel Georg
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199506431
Subject(s) - ribozyme , hammerhead ribozyme , hairpin ribozyme , pairing , base pair , mammalian cpeb3 ribozyme , förster resonance energy transfer , chemistry , crystallography , physics , stereochemistry , fluorescence , rna , dna , biochemistry , gene , quantum mechanics , superconductivity
Two methods—one result: Through fluorescence energy transfer measurements and an X‐ray structure analysis on ribozyme–substrate complexes, the groups of Eckstein and McKay independently arrived at a largely consistent structural model for hammerhead ribozymes. Three helices are arranged in a stretched Y shape (see picture) and are stabilized by unusual interactions besides the Watson‐Crick base pairing.