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DNA–Carbohydrate Recognition: Design and Synthesis of an Eight‐Base Sequence‐Selective DNA‐Binding Oligosaccharide
Author(s) -
Nicolaou K. C.,
Ajito Keiichi,
Komatsu Hironori,
Smith Brian M.,
Li Tianhu,
Egan Miles G.,
GomezPaloma Luigi
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199505761
Subject(s) - oligosaccharide , dna , dna sequencing , biochemistry , chemistry , cleavage (geology) , base pair , minor groove , biology , paleontology , fracture (geology)
A decacyclic oligosaccharide was designed to dock into the minor groove of duplex DNA selectively at a TCCTXXAGGA sequence. Competition experiments with calicheamicin γ 1 Irevealed that the oligosaccharide inhibits DNA cleavage and exhibits high DNA binding affinity.