Modified Triple Resonance NMR Experiments with Optimized Sensitivity for Rapidly Exchanging Protons | Zendy

Jahnke Wolfgang | Zendy; Kessler Horst | Zendy

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Modified Triple Resonance NMR Experiments with Optimized Sensitivity for Rapidly Exchanging Protons

Author(s) -

Jahnke Wolfgang,

Kessler Horst

Publication year - 1995

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199504691

Subject(s) - pulse sequence , amide , nuclear magnetic resonance , sensitivity (control systems) , chemistry , resonance (particle physics) , residue (chemistry) , pulse (music) , analytical chemistry (journal) , materials science , physics , atomic physics , chromatography , organic chemistry , optics , electronic engineering , detector , engineering

Fast exchange with surrounding water protons need not attenuate 1 H NMR signals of proteins in solution. A modified pulse sequence has been developed to increase the signal intensity of the amide protons; on the right the improvement in sensitivity (a → c) is shown for a selected residue in a protein. This new technique should aid elucidation of protein structures in solution.

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