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Synthesis, Antitumor Activity, and Tolerability of Phospholipids Containing Nitrogen Homologues
Author(s) -
Stekar Jurij,
Nössner Gerhard,
Kutscher Bernhard,
Engel Jürgen,
Hilgard Peter
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199502381
Subject(s) - tolerability , nitrogen atom , chemistry , stereochemistry , liposome , biochemistry , combinatorial chemistry , pharmacology , organic chemistry , medicine , group (periodic table) , adverse effect
Replacing the N atom with an As or P atom in antineoplastically active phospholipids 1 and 2 (Z N) leads to homologous compounds (Z As, P) that are equally effective against tumors and have fewer side effects than the N‐containing phospholipids. This marks definite progress in cancer treatment with chemotherapeutically active phospholipids.