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The Formation of a Mixed Organolithium Aggregate Li 4 R 2 n Bu 2 during the Heteroatom‐Assisted Lithiation of 1,3‐Bis(dimethylaminomethyl)‐2,4,6‐trimethylbenzene (R = 2,6‐(CH 2 NMe 2 ) 2 ‐3,5‐Me 2 C 6 HCH 2 )
Author(s) -
Wijkens Peter,
van Koten Ernout M.,
Janssen Maurits D.,
Jastrzebski Johann T. B. H.,
Spek Anthony L.,
van Koten Gerard
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199502191
Subject(s) - heteroatom , butyllithium , chemistry , lithium (medication) , aggregate (composite) , medicinal chemistry , organic chemistry , materials science , ring (chemistry) , nanotechnology , medicine , endocrinology
Lithiated 1 and unreacted n ‐butyllithium in a 2:2 ratio make up the title aggregate 2 , which is formed in the reaction of 1 with two equivalents of n ‐butyllithium (shown below). Species such as 2 can be regarded as intermediates in heteroatom‐facilitated lithiation reactions.