Micron‐Scale Patterning of Biological Molecules | Zendy

Pritchard David John | Zendy; Morgan Hywel | Zendy; Cooper Jonathan Mark | Zendy

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Micron‐Scale Patterning of Biological Molecules

Author(s) -

Pritchard David John,

Morgan Hywel,

Cooper Jonathan Mark

Publication year - 1995

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199500911

Subject(s) - analyte , nanotechnology , avidin , materials science , molecule , silicon dioxide , silicon , ligand (biochemistry) , chemistry , receptor , optoelectronics , biotin , chromatography , biochemistry , organic chemistry , composite material

Site‐specific attachment of biological molecules on gold and silicon dioxide surfaces has been achieved: The surface is modified with the receptor/ligand pair avidin D/photobiotin 1 and exposed to light through a mask in the presence of a protein solution; binding only occurs in the exposed areas. After unbound material is removed by washing, this process can be repeated several times to produce a two‐dimensional pattern. One of the potential applications of this technique is the patterning of antibodies in a format that can be used in a multi‐analyte immunosensor.

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