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Novel Bimetallic Model System for Cytochrome P 450 : Effect of Membrane Environment on the Catalytic Oxidation
Author(s) -
Schenning Albertus P. H. J.,
Hubert Dominicus H. W.,
van Esch Jan H.,
Feiters Martinus C.,
Nolte Roeland J. M.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199424681
Subject(s) - bimetallic strip , catalysis , chemistry , cytochrome , membrane , cytochrome p450 , enzyme , combinatorial chemistry , stereochemistry , photochemistry , organic chemistry , biochemistry
A novel membrane‐bound cytochrome P 450 mimic (shown schematically below, 1 : a Rh III complex, 2 : a manganoporphyrin) catalyzes the epoxidation of alkenes with dioxygen. The turnover numbers achieved with this catalyst are in the same range as those obtained with the natural enzyme.