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Fullerene–Oligonucleotide Conjugates: Photoinduced Sequence‐Specific DNA Cleavage
Author(s) -
Boutorine Alexandre S.,
Takasugi Masashi,
Hélène Claude,
Tokuyama Hidetoshi,
Isobe Hiroyuki,
Nakamura Eiichi
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199424621
Subject(s) - oligonucleotide , conjugate , cleavage (geology) , duplex (building) , guanine , dna , singlet oxygen , chemistry , fullerene , stereochemistry , combinatorial chemistry , oxygen , biochemistry , materials science , nucleotide , gene , organic chemistry , mathematical analysis , mathematics , fracture (geology) , composite material
The guanine‐specific cleavage of oligonucleotides is achieved with the conjugate 1 , which contains a fullerene tethered to a tetradecadeoxyribonucleotide Nu(pNu) n . This conjugate was able to form a duplex with a complementary oligonucleotide, and triplexes with appropriate double‐stranded oligonucleotides. Irradiation of the complexes leads to site‐specfic cleavage of the target sequences—probably through the action of singlet oxygen.