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A Short Route to [3‐ 15 N]‐3′‐Azido‐3′‐deoxythymidine (N3‐Labeled AZT) via 3‐Nitro‐AZT
Author(s) -
Ariza Xavier,
Bou Valentí,
Vilarrasa Jaume,
Tereshko Valya,
Campos J. L.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199424541
Subject(s) - nucleic acid , pyrimidine , nitro , zidovudine , stereochemistry , chemistry , nucleoside , combinatorial chemistry , human immunodeficiency virus (hiv) , biochemistry , virology , biology , organic chemistry , alkyl , viral disease
Nucleosides with appropriate isotopic labels are crucial for studies of nucleic acid structures, drug‐binding phenomena, and related molecular recognition processes. A mild and general approach for the introduction of 15 N at the 3‐position of pyrimidine nucleosides is illustrated by the conversion of AZT to [3‐ 15 N]‐AZT 1 ( * = isotopically labeled).