Premium
Diastereomerically Pure Mannich Bases from the Addition of Enamines to Ternary Iminium Salts
Author(s) -
Risch Nikolaus,
Arend Michael
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199424221
Subject(s) - iminium , ternary operation , mannich reaction , chemistry , organic chemistry , reaction conditions , combinatorial chemistry , computer science , catalysis , programming language
Very high yields and diastereoselectivities , mild reaction conditions, a straightforward experimental procedure, and cheap starting materials—these are the advantages offered by the reaction of ( E )‐enamines 1 with iminium salts 2 to give the Mannich bases 3 . Since Mannich bases are important synthetic building blocks for Pharmaceuticals and natural products, this reaction will surely prove to be extremely useful.