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The Key–Lock Theory and the Induced Fit Theory
Author(s) -
Koshland Daniel E.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199423751
Subject(s) - lock (firearm) , key (lock) , computer science , engineering , computer security , mechanical engineering
As a glove changes shape when a hand slips into it , so an enzyme changes its conformation on binding a ligand. This theory of induced fit extends the lock‐and‐key principle that Emil Fischer proposed exactly 100 years ago. The new theory proposed by D. E. Koshland, Jr. in 1958 allows one to explain regulation and cooperative effects, and adds some new specificity principles as well.