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Totally Enantioselective Inversion of Configuration of ( S )‐(+)‐Carnitine Derivatives
Author(s) -
Bernabei Ida,
Castagnani Roberto,
De Angelis Francesco,
De Witt Scalfaro Paolo,
Giannessi Fabio,
Misiti Domenico,
Muck Sandra,
Scafetta Nazareno,
Tinti Maria Ornella
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199420761
Subject(s) - enantioselective synthesis , yield (engineering) , carnitine , inversion (geology) , combinatorial chemistry , chemistry , stereochemistry , lactone , sequence (biology) , mathematics , organic chemistry , materials science , catalysis , biology , biochemistry , paleontology , structural basin , metallurgy
Tons of waste ( S )‐carnitinamide 1 are obtained in the industrial production of the ( R ) isomer 3 , which is a biologically active pharmaceutical product. A method has now been developed to recycle 1 in a five‐step reaction sequence with 80% overall yield via β‐lactone 2 .