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Synthesis and Selective Radical Cleavage of C‐4′‐Modified Oligonucleotides
Author(s) -
Giese Bernd,
Dussy Adrian,
Elie Cornelius,
Erdmann Peter,
Schwitter Urs
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199418611
Subject(s) - oligonucleotide , bond cleavage , cleavage (geology) , chemistry , aqueous solution , combinatorial chemistry , dna , stereochemistry , organic chemistry , materials science , biochemistry , catalysis , fracture (geology) , composite material
Fragments 3 and 4 are formed selectively upon irradiation of 2 in aqueous solution. This proves that sites of DNA strand scission can be designated by incorporation of 1 in oligonucleotides.