Premium
Isofagomine, a Potent, New Glycosidase Inhibitor
Author(s) -
Jespersen Tina M.,
Dong Wenling,
Sierks Michael R.,
Skrydstrup Troels,
Lundt Inge,
Bols Mikael
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199417781
Subject(s) - glycoside hydrolase , ring (chemistry) , chemistry , anomer , stereochemistry , atom (system on chip) , derivative (finance) , glucosidases , monosaccharide , enzyme , biochemistry , organic chemistry , computer science , economics , financial economics , embedded system
Replacing the anomeric C atom of 2‐deoxy‐ O ‐glucose with an N atom and the ring O atom with a C atom leads to 1 , the most potent β‐glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom.