Isofagomine, a Potent, New Glycosidase Inhibitor | Zendy

Jespersen Tina M. | Zendy; Dong Wenling | Zendy; Sierks Michael R. | Zendy; Skrydstrup Troels | Zendy; Lundt Inge | Zendy; Bols Mikael | Zendy

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Isofagomine, a Potent, New Glycosidase Inhibitor

Author(s) -

Jespersen Tina M.,

Dong Wenling,

Sierks Michael R.,

Skrydstrup Troels,

Lundt Inge,

Bols Mikael

Publication year - 1994

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199417781

Subject(s) - glycoside hydrolase , ring (chemistry) , chemistry , anomer , stereochemistry , atom (system on chip) , derivative (finance) , glucosidases , monosaccharide , enzyme , biochemistry , organic chemistry , computer science , economics , financial economics , embedded system

Replacing the anomeric C atom of 2‐deoxy‐ O ‐glucose with an N atom and the ring O atom with a C atom leads to 1 , the most potent β‐glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom.

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