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A New Synthetic Route to 1,2‐Dihydrocyclobutaarenes
Author(s) -
Toda Fumio,
Tanaka Koichi,
Sano Isao,
Isozaki Toru
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199417571
Subject(s) - sequence (biology) , chemistry , combinatorial chemistry , stereochemistry , biochemistry
In a two‐ or three‐step sequence , dihydrocyclobutabenzene derivatives 4 can be obtained from 1,2‐dihalocycloalkenes or ortho ‐dihaloarenes 1 (see below). The intermediate allenes 3 need not and cannot always be isolated, because cyclization occurs at room temperature. X Cl, Br.