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Synthesis of Cyclotheonamide B and Its Derivatives
Author(s) -
Deng Jingen,
Hamada Yasumasa,
Shioiri Takayuki,
Matsunaga Shigeki,
Fusetani Nobuhiro
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199417291
Subject(s) - pentapeptide repeat , serine protease , stereochemistry , chemistry , protease , combinatorial chemistry , biochemistry , enzyme , peptide
A high‐yielding macrolactonization is the key step in the convergent synthesis of the macrocyclic pentapeptide 1 . The hydroxy derivatives 1b and 1c are not inhibitors of serine protease, since they do not have the α‐carbonylamide unit (X, Y O) found in the naturally occurring cyclotheonamide B ( 1a ).
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