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Cover Picture (Angew. Chem. Int. Ed. Engl. 17/1994)
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199416751
Subject(s) - liposome , cover (algebra) , nanotechnology , chemistry , lipid bilayer , polymer science , computer science , materials science , engineering , mechanical engineering , biochemistry , membrane
The cover picture shows schematically a liposome with a protective polymer coating encapsulating a drug. Such sterically stabilized “Stealth liposomes” in which the polymer chains are anchored in the lipid bilayer are much more stable under biological conditions than the classical, unprotected liposomes. The extended circulation achieved is crucial for cell‐specific targetting of the drug. X‐ray scattering and electron microscopy have shown that the encapsulated drug is precipitated, which greatly enhances the encapsulation efficiency and stability. Danilo D. Lasic reports more about this new generation of liposomes on p. 1685ff. The picture was designed by Alenka D. Lasic.