Premium
Synthesis of an Azathymidine and Its Incorporation into Oligonucleotides
Author(s) -
Altmann KarlHeinz,
Freier Susan M.,
Pieles Uwe,
Winkler Tammo
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199416541
Subject(s) - oligonucleotide , chemistry , thymidine , combinatorial chemistry , rna , serine , biochemistry , stereochemistry , enzyme , dna , gene
Increased stability towards enzymatic degradation is observed for oligonucleotides if they contain the thymidine analogue 1 . Its binding ability for complementary RNA is not decreased significantly, which makes 1 interesting as a building block for antisense oligonucleotides. Compound 1 can be prepared in a nineteen‐step synthesis starting from D ‐serine.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom