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Biosynthetic Investigations on Pyridazomycin
Author(s) -
Bockholt Heike,
Beale John M.,
Rohr Jürgen
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199416481
Subject(s) - glycine , bacteria , chemistry , ornithine , biochemistry , streptomyces , metabolism , biosynthesis , citrate synthase , amino acid , stereochemistry , biology , arginine , enzyme , genetics
An unexpected amino acid metabolism is used by a subspecies of the soil bacterium Streptomyces violaceoniger to produce the antifungal antibiotic pyridazomycin 1 ‐C1. Feeding studies with isotopically labeled precursors indicate that 1 is constructed from ornithine, glycine, and probably oxaloacetate.