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A Water‐Soluble Prodrug of Taxol with Self‐Assembling Properties
Author(s) -
Nicolaou Kyriacos Costa,
Guy Rodney Kiplin,
Pitsinos Emmanuel Nicolauo,
Wrasidlo Wolfgang
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199415831
Subject(s) - prodrug , water soluble , derivative (finance) , chemistry , combinatorial chemistry , pharmacology , stereochemistry , organic chemistry , biochemistry , medicine , business , finance
Just as effective and not as toxic , taxol derivative 1 displays antitumor activity comparable to that of the parent compound. Since 1 is water soluble, complications that arise in clinical applications of taxol may be avoided.