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Binary Encoding of Compound Libraries
Author(s) -
Eckes Peter
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199415731
Subject(s) - encoding (memory) , identification (biology) , binary number , supramolecular chemistry , computer science , molecule , simple (philosophy) , combinatorial chemistry , scheme (mathematics) , small molecule , chemistry , computational biology , nanotechnology , materials science , mathematics , biology , artificial intelligence , organic chemistry , arithmetic , biochemistry , philosophy , botany , epistemology , mathematical analysis
The rapid identification of functional molecules that participate in specific supramolecular interactions is a major problem in the screening of compound libraries. The binary encoding developed by Still et al. allows the structure assignment of “active” compounds according to a simple encoding scheme, and is independent of the synthetic chemistry employed. The viability of this concept has already been demonstrated, but the advantages will first be fully realized with libraries of small organic molecules.