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Metal Complexes of Marine Peptide Metabolites: A Novel Ag 4 Cluster
Author(s) -
Wipf Peter,
Venkatraman Srikanth,
Miller Chris P.,
Geib Steven J.
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199415161
Subject(s) - cooperativity , peptide , chemistry , chelation , cluster (spacecraft) , metal , metal ions in aqueous solution , stereochemistry , crystallography , combinatorial chemistry , inorganic chemistry , biochemistry , organic chemistry , computer science , programming language
Silver( I ) ions are bound selectively and with high cooperativity to the peptide westiellamide obtained from Lisso‐clinum . The complex contains a unique [Ag4] 4+ cluster sandwiched between two neutral macrocyclic ligands (see structure on the right). The importance of metal chelation for the biological activity is currently under investigation.