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A Highly Convergent Synthesis of the Lewis y Blood Group Determinant in Conjugatable Form
Author(s) -
Behar Victor,
Danishefsky Samuel J.
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199414681
Subject(s) - glycosyl , glycoprotein , oligosaccharide , glycosylation , chemistry , group (periodic table) , glycosyl donor , carbohydrate , stereochemistry , biochemistry , organic chemistry
The versatility of glycals both as glycosyl donors and as glycosyl acceptors is used in the synthesis of the Lewis y determinant. This and the oligosaccharide described in the following communication consist of a determinant, a carbohydrate spacer, and a group suitable for the conjugation to a carrier protein. The spacer present in these new glycoproteins minimizes the likelihood that the protein carrier will distort the recognition property of the determinant.