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New Cyclic Derivatives of 3′‐Amino‐3′‐deoxy‐adenosine‐5′‐diphosphate, ‐triphosphate, and ‐methylenebis(phosphonate)
Author(s) -
Morr Michael,
Wray Victor
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199413941
Subject(s) - carbodiimide , chemistry , intramolecular force , phosphonate , ring (chemistry) , hydrochloride , adenosine triphosphate , stereochemistry , derivative (finance) , medicinal chemistry , polymer chemistry , organic chemistry , financial economics , economics
A ten‐membered ring system forms part of the adenosine derivative 2 , which can be prepared from triphosphate 1 by an intramolecular condensation with the water‐soluble carbodiimide l‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride (EDC); analogous compounds with six‐ and eight‐membered ring systems are accessible from the corresponding mono‐ and diphosphates, respectively. Compounds of this kind are of interest, for instance, as potential enzyme inhibitors. A = adenyl.