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Split Genes and RNA Splicing (Nobel Lecture)
Author(s) -
Sharp Phillip A.
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199412291
Subject(s) - intron , spliceosome , rna splicing , group ii intron , gene , genetics , rna , minor spliceosome , biology , group i catalytic intron , post transcriptional modification , computational biology
The discovery in 1977 that genes of eukaryotic organisms contain nonsense segments (“introns”) earned P. A. Sharp the 1993 Nobel Prize for Medicine. The introns at the stage of RNA are displaced by spliceosomes or in a self‐splicing process (outlined schematically below). A denotes an adenosine residue, P phosphate groups, the rectangles RNA sequences that are joined together, and the lines the intron that is spliced.