An Amazing Distortion in DNA Induced by a Methyltransferase (Nobel Lecture) | Zendy

Roberts Richard J. | Zendy

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An Amazing Distortion in DNA Induced by a Methyltransferase (Nobel Lecture)

Author(s) -

Roberts Richard J.

Publication year - 1994

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199412221

Subject(s) - dna , helix (gastropod) , dna methyltransferase , base pair , biophysics , methyltransferase , chemistry , crystallography , biology , biochemistry , methylation , ecology , snail

Not a bend or kink in the DNA , but the flip of the base to be methylated out the DNA helix (picture on the right) occurs when a methyltransferase binds to DNA. This was the key result of the X‐ray structure analysis of a ternary complex of M. Hha I, AdoMet, and a 5‐fluorocytosine‐substituted DNA double helix. This conformational shift may generally play a major role in the opening up of DNA helices.

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